Sickle Cell Epidemiology

Description Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red...

Sickle Cell Genetics – HBB Gene

Normal Function The HBB gene provides instructions for making a protein called beta-globin. Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells. In adults, hemoglobin normally consists of four protein...

Nephrotic Syndrome Genetics

Description Congenital nephrotic syndrome is a kidney condition that begins in infancy and typically leads to irreversible kidney failure (end-stage renal disease) by early childhood. Children with congenital nephrotic syndrome begin to have symptoms of the condition...

Kawasaki Disease Genetics

Description Kawasaki disease is a sudden and time-limited (acute) illness that affects infants and young children. Affected children develop a prolonged fever lasting several days, a skin rash, and swollen lymph nodes in the neck (cervical lymphadenopathy). They also...

Ticks and Lyme Disease

Ticks and Lyme Disease: Symptoms, Treatment, and Prevention Tick-borne diseases such as Lyme disease are on the rise. Reported cases in the United States increased from about 12,000 annually in 1995 to approximately 36,000 per year from 2013 – 2016, according to...