fbpx

Multiple Myeloma Treatment

Learn

There are different types of treatment for patients with plasma cell neoplasms. Eight types of treatment are used:

  • Eight types of treatment are used:
    • Chemotherapy
    • Other drug therapy
    • Targeted therapy
    • High-dose chemotherapy with stem cell transplant
    • Biologic therapy
    • Radiation therapy
    • Surgery
    • Watchful waiting
  • New types of treatment are being tested in clinical trials.
    • New combinations of therapies
  • Supportive care is given to lessen the problems caused by the disease or its treatment.
  • Patients may want to think about taking part in a clinical trial.
  • Patients can enter clinical trials before, during, or after starting their cancer treatment.
  • Follow-up tests may be needed.

 

Chemotherapy

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.

 

Other drug therapy

Corticosteroids are steroids that have antitumor effects in multiple myeloma.

 

Targeted therapy

Targeted therapy is a treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells. Several types of targeted therapy may be used to treat multiple myeloma and other plasma cell neoplasms.

Proteasome inhibitor therapy is a type of targeted therapy that blocks the action of proteasomes in cancer cells and may prevent the growth of tumors. Bortezomib, carfilzomib, and ixazomib are proteasome inhibitors used in the treatment of multiple myeloma and other plasma cell neoplasms.

Monoclonal antibody therapy is a cancer treatment that uses antibodies made in the laboratory, from a single type of immune system cell. These antibodies can identify substances on cancer cells or normal substances that may help cancer cells grow. The antibodies attach to the substances and kill the cancer cells, block their growth, or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells. Daratumumab and elotuzumab are monoclonal antibodies used in the treatment of multiple myeloma and other plasma cell neoplasms.

Histone deacetylase (HDAC) inhibitor therapy is a type of targeted therapy that blocks enzymes needed for cell division and may stop the growth of cancer cells. Panobinostat is an HDAC inhibitor used in the treatment of multiple myeloma and other plasma cell neoplasms.

 

High-dose chemotherapy with stem cell transplant

This treatment is a way of giving high doses of chemotherapy and replacing blood -forming cells destroyed by the cancer treatment. Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient (autologous transplant) or a donor (allogeneic transplant) and are frozen and stored. After the chemotherapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body’s blood cells.

 

Biologic therapy

Biologic therapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer. This type of cancer treatment is also called biotherapy or immunotherapy.

Immunomodulators are a type of biologic therapy. Thalidomide, lenalidomide, and pomalidomide are immunomodulators used to treat multiple myeloma and other plasma cell neoplasms.

Interferon is a type of biologic therapy. It affects the division of cancer cells and can slow tumor growth.

 

Radiation therapy

Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy:

  • External radiation therapy uses a machine outside the body to send radiation toward the cancer.
  • Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer.

The way the radiation therapy is given depends on the type and stage of the cancer being treated. External radiation therapy is used to treat plasma cell neoplasms.

Surgery

Surgery to remove the tumor may be done and is usually followed by radiation therapy. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

Watchful waiting

Watchful waiting is closely monitoring a patient’s condition without giving any treatment until signs or symptoms appear or change.

New combinations of therapies

Clinical trials are studying different combinations of biologic therapy, chemotherapy, steroid therapy, and drugs. New treatment regimens using thalidomide or lenalidomide are also being studied.

Supportive care is given to lessen the problems caused by the disease or its treatment.

This therapy controls problems or side effects caused by the disease or its treatment, and improves quality of life. Supportive care is given to treat problems caused by multiple myeloma and other plasma cell neoplasms.

Supportive care may include the following:

  • Plasmapheresis: If the blood becomes thick with extra antibody proteins and interferes with circulation, plasmapheresis is done to remove extra plasma and antibody proteins from the blood. In this procedure blood is removed from the patient and sent through a machine that separates the plasma (the liquid part of the blood) from the blood cells. The patient’s plasma contains the unneeded antibodies and is not returned to the patient. The normal blood cells are returned to the bloodstream along with donated plasma or a plasma replacement. Plasmapheresis does not keep new antibodies from forming.
  • High-dose chemotherapy with stem cell transplant: If amyloidosis occurs, treatment may include high-dose chemotherapy followed by stem cell transplant using the patient’s own stem cells.
  • Biologic therapy: Biologic therapy with thalidomide, lenalidomide, or pomalidomide is given to treat amyloidosis.
  • Targeted therapy: Targeted therapy with proteasome inhibitors is given to treat amyloidosis.
  • Radiation therapy: Radiation therapy is given for bone lesions of the spine.
  • Chemotherapy: Chemotherapy is given to reduce back pain from osteoporosis or compression fractures of the spine.
  • Bisphosphonate therapy: Bisphosphonate therapy is given to slow bone loss and reduce bone pain

Treatment Options for Plasma Cell Neoplasms

Monoclonal Gammopathy of Undetermined Significance

Treatment of monoclonal gammopathy of undetermined significance (MGUS) is usually watchful waiting. Regular blood tests to check the level of M protein in the blood and physical exams to check for signs or symptoms of cancer will be done.

Isolated Plasmacytoma of Bone

Treatment of isolated plasmacytoma of bone is usually radiation therapy to the bone lesion.

Extramedullary Plasmacytoma

Treatment of extramedullary plasmacytoma may include the following:

  • Radiation therapy to the tumor and nearby lymph nodes.
  • Surgery, usually followed by radiation therapy.
  • Watchful waiting after initial treatment, followed by radiation therapy, surgery, or chemotherapy if the tumor grows or causes signs or symptoms.

Multiple Myeloma

Patients without signs or symptoms may not need treatment. When signs or symptoms appear, the treatment of multiple myeloma may be done in phases:

  • Induction therapy : This is the first phase of treatment. Its goal is to reduce the amount of disease, and may include one or more of the following:
    • Corticosteroid therapy.
    • Biologic therapy with lenalidomide, pomalidomide, or thalidomide therapy.
    • Targeted therapy with proteasome inhibitors (bortezomib, carfilzomib, and ixazomib) or monoclonal antibodies (daratumumab and elotuzumab).
    • Chemotherapy.
    • Histone deacetylase inhibitor therapy with panobinostat.
    • A clinical trial of different combinations of treatment.
  • Consolidation chemotherapy : This is the second phase of treatment. Treatment in the consolidation phase is to kill any remaining cancer cells. High-dose chemotherapy is followed by either:
    • one autologous stem cell transplant, in which the patient’s stem cells from the blood or bone marroware used; or
    • two autologous stem cell transplants followed by an autologous or allogeneic stem cell transplant, in which the patient receives stem cells from the blood or bone marrow of a donor; or
    • one allogeneic stem cell transplant.
  • Maintenance therapy : After the initial treatment, maintenance therapy is often given to help keep the disease in remission for a longer time. Several types of treatment are being studied for this use, including the following:
    • Chemotherapy.
    • Biologic therapy with interferon.
    • Corticosteroid therapy.
    • Lenalidomide therapy.
    • Targeted therapy with a proteasome inhibitor (bortezomib).

Refractory Multiple Myeloma

Treatment of refractory multiple myeloma may include the following:

  • Watchful waiting for patients whose disease is stable.
  • A different treatment than treatment already given, for patients whose tumor kept growing during treatment. (See Multiple Myeloma treatment options.)
  • A clinical trial of a new therapy.

 

Source:

https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq#secti…

Hyperlink:
https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq#section/all